Assembly of the genome of the disease vector Aedes aegypti onto a genetic linkage map allows mapping of genes affecting disease transmission.

doi:10.1371/journal.pntd.0002652

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Article

Assembly of the genome of the disease vector Aedes aegypti onto a genetic linkage map allows mapping of genes affecting disease transmission.

PLoS neglected tropical diseases - 1 Jan 2014

Juneja Punita, Osei-Poku Jewelna, Ho Yung S, Ariani Cristina V, Palmer William J, Pain Arnab, Jiggins Francis M

Abstract excerpt

The mosquito Aedes aegypti transmits some of the most important human arboviruses, including dengue, yellow fever and chikungunya viruses. It has a large genome containing many repetitive sequences, which has resulted in the genome being poorly assembled - there are 4,758 scaffolds, few of which have been assigned to a chromosome. To allow the mapping of genes affecting disease transmission, we have improved the...

Topics

Aedes
Animals
Chromosome Mapping
Genes, Insect
Genome, Insect
Insect Vectors
Polymorphism, Single Nucleotide

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PMID: 24498447
DOI: 10.1371/journal.pntd.0002652
PMCID: PMC3907309

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