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Thrombophilic mutations and polymorphisms, alone or in combination, and recurrent spontaneous abortion.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 May 2015

Lino Fabio L, Traina Évelyn, Barreto José Augusto, Moron Antonio Fernandes, Mattar Rosiane

Abstract excerpt

Generally, recurrent spontaneous abortions (RSAs) have no identifiable cause; yet, vascular alterations during pregnancy may be associated with pregnancy loss. Therefore, we evaluated the association between thrombophilic mutations and RSAs. This case-control study was conducted in 112 patients who had RSAs and 98 health control women. Genomic DNA was extracted from whole blood, and polymorphism genotyping was...

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PMID: 24463599
DOI: 10.1177/1076029613520465

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