Complete posttranslational modification mapping of pathogenic <i><scp>N</scp>eisseria meningitidis</i> pilins requires top‐down mass spectrometry

Abstract excerpt

In pathogenic bacteria, posttranslationally modified proteins have been found to promote bacterial survival, replication, and evasion from the host immune system. In the human pathogen Neisseria meningitidis, the protein PilE (15-18 kDa) is the major building block of type IV pili, extracellular filamentous organelles that play a major role in mediating pathogenesis. Previous reports have shown that PilE can be...

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