Article
Changes in right heart haemodynamics and echocardiographic function in an advanced phenotype of pulmonary hypertension and right heart dysfunction associated with pulmonary fibrosis.
Thorax - 1 Feb 2014
Saggar Rajeev, Khanna Dinesh, Vaidya Anjali, Derhovanessian Ariss, Maranian Paul, Duffy Erin, Belperio John A, Weigt Sam S, Dua Shiv, Shapiro Shelley S, Goldin Jonathan G, Abtin Fereidoun, Lynch Joseph P, Ross David J, Forfia Paul R, Saggar Rajan
Abstract excerpt
BACKGROUND: Pulmonary hypertension (PH)-targeted therapy in the setting of pulmonary fibrosis (PF) is controversial; the main clinical concern is worsening of systemic hypoxaemia. We sought to determine the effects of gentle initiation and chronic administration of parenteral treprostinil on right heart function in patients with PF associated with an advanced PH phenotype. METHODS: Open-label, prospective...
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