Article
Genetic influence on exercise-induced changes in physical function among mobility-limited older adults.
Physiological genomics - 1 Mar 2014
Buford Thomas W, Hsu Fang-Chi, Brinkley Tina E, Carter Christy S, Church Timothy S, Dodson John A, Goodpaster Bret H, McDermott Mary M, Nicklas Barbara J, Yank Veronica, Johnson Julie A, Pahor Marco
Abstract excerpt
To date, physical exercise is the only intervention consistently demonstrated to attenuate age-related declines in physical function. However, variability exists in seniors' responsiveness to training. One potential source of variability is the insertion (I allele) or deletion (D allele) of a 287 bp fragment in intron 16 of the angiotensin-converting enzyme (ACE) gene. This polymorphism is known to influence a...
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