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Article

Towards a unified model of RAF inhibitor resistance.

Cancer discovery - 1 Jan 2014

Solit David B, Rosen Neal

Abstract excerpt

ATP-competitive RAF inhibitors elicit profound but often temporary antitumor responses in patients with BRAF-mutant melanoma. Analysis of tumor samples collected at the time of disease progression indicates that alterations within the extracellular signal-regulated kinase (ERK) pathway that result in reactivation of ERK signaling are present in most patients. Mutations in the phosphoinositide 3-kinase/AKT pathway...

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Topics

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Share to Antineoplastic Agents
Share to Drug Resistance, Neoplasm
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRAF gene

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 24402945
DOI: 10.1158/2159-8290.CD-13-0961
PMCID: PMC4986142

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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