Article
Change of point mutations in Helicobacter pylori rRNA associated with clarithromycin resistance in Italy.
Journal of medical microbiology - 1 Mar 2014
De Francesco Vincenzo, Zullo Angelo, Giorgio Floriana, Saracino Ilaria, Zaccaro Cristina, Hassan Cesare, Ierardi Enzo, Di Leo Alfredo, Fiorini Giulia, Castelli Valentina, Lo Re Giovanna, Vaira Dino
Abstract excerpt
Primary clarithromycin resistance is the main factor affecting the efficacy of Helicobacter pylori therapy. This study aimed: (i) to assess the concordance between phenotypic (culture) and genotypic (real-time PCR) tests in resistant strains; (ii) to search, in the case of disagreement between the methods, for point mutations other than those reported as the most frequent in Europe; and (iii) to compare the MICs...
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