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Article

Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum.

Chembiochem : a European journal of chemical biology - 24 Jan 2014

Liu Weidong, Li Zhe, Huang Chun-Hsiang, Guo Rey-Ting, Zhao Leiming, Zhang Dalong, Chen Xi, Wu Qiaqing, Zhu Dunming

Abstract excerpt

Wild-type meso-diaminopimelate dehydrogenase (DAPDH) is usually specific to the native substrate, meso-2,6-diaminopimelate. Recently, a DAPDH from Symbiobacterium thermophilum (StDAPDH) was found to exhibit expanded substrate specificity. As such, its crystal structures in apo form and in complex with NADP(+) and both NADPH and meso-DAP were investigated to reveal the structural basis of its unique catalytic...

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PMID: 24339368
DOI: 10.1002/cbic.201300691

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DAP

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