Article
Lack of isocitrate lyase in Chlamydomonas leads to changes in carbon metabolism and in the response to oxidative stress under mixotrophic growth.
The Plant journal : for cell and molecular biology - 1 Feb 2014
Plancke Charlotte, Vigeolas Helene, Höhner Ricarda, Roberty Stephane, Emonds-Alt Barbara, Larosa Véronique, Willamme Remi, Duby Franceline, Onga Dhali David, Thonart Philippe, Hiligsmann Serge, Franck Fabrice, Eppe Gauthier, Cardol Pierre, Hippler Michael, Remacle Claire
Abstract excerpt
Isocitrate lyase is a key enzyme of the glyoxylate cycle. This cycle plays an essential role in cell growth on acetate, and is important for gluconeogenesis as it bypasses the two oxidative steps of the tricarboxylic acid (TCA) cycle in which CO₂ is evolved. In this paper, a null icl mutant of the green microalga Chlamydomonas reinhardtii is described. Our data show that isocitrate lyase is required for growth in...
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