Polysome profiling reveals translational control of gene expression in the human malaria parasite Plasmodium falciparum

Abstract excerpt

BACKGROUND: In eukaryotic organisms, gene expression is regulated at multiple levels during the processes of transcription and translation. The absence of a tight regulatory network for transcription in the human malaria parasite suggests that gene expression may largely be controlled at post-transcriptional and translational levels. RESULTS: In this study, we compare steady-state mRNA and polysome-associated...

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