Article
Molecular characterization and genome-wide mutations in porcine anal atresia candidate gene GLI2.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2013
Jin Qiushi, Wang Chao, Li Xinyun, Yu Mei, Zhao Shu-hong, Li Xiaoping
Abstract excerpt
Anal atresia (i.e., anorectal malformations) is a severe disorder that occurs during the development of the distal hindgut in infants, swine, and many other mammals and has an unclear genetic background. Recently, the Shh-responsive transcription factor GLI2 has been shown as essential to the normal development of the hindgut, and QTL studies in pigs revealed that this gene may be an important candidate for anal...
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