Article
Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells.
Brain, behavior, and immunity - 1 Jul 2014
Bigley Austin B, Rezvani Katayoun, Chew Claude, Sekine Takuya, Pistillo Mira, Crucian Brian, Bollard Catherine M, Simpson Richard J
Abstract excerpt
NK-cells undergo a "licensing" process as they develop into fully-functional cells capable of efficiently killing targets. NK-cell differentiation is accompanied by an increased surface expression of inhibitory killer immunoglobulin-like receptor (KIR) molecules, which is positively associated with cytotoxicity against the HLA-deficient K562 cell line. NK-cells are rapidly redeployed between the blood and tissues...
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