Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections

doi:10.1128/jvi.02589-13

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Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections

31 Oct 2013

Abstract excerpt

At mucosal sites, papillomavirus genomes can persist in the epithelial basal layer following immune-mediated regression. Subsequent T-cell depletion stimulates a 3- to 5-log increase in the viral copy number, to levels associated with productive infection. Reappearance of microlesions was rare within the short time frame of our experiments but was observed in one instance. Our studies provide direct evidence that...

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PMID: 24173230
DOI: 10.1128/jvi.02589-13

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