Article
Ectopic KIT copy number variation underlies impaired migration of primordial germ cells associated with gonadal hypoplasia in cattle (Bos taurus).
PloS one - 1 Jan 2013
Venhoranta Heli, Pausch Hubert, Wysocki Michal, Szczerbal Izabela, Hänninen Reetta, Taponen Juhani, Uimari Pekka, Flisikowski Krzysztof, Lohi Hannes, Fries Ruedi, Switonski Marek, Andersson Magnus
Abstract excerpt
Impaired migration of primordial germ cells during embryonic development causes hereditary gonadal hypoplasia in both sexes of Northern Finncattle and Swedish Mountain cattle. The affected gonads exhibit a lack of or, in rare cases, a reduced number of germ cells. Most affected animals present left-sided gonadal hypoplasia. However, right-sided and bilateral cases are also found. This type of gonadal hypoplasia...
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