Simple and rapid enzyme-linked immunosorbent assay for the detection of hemoglobin C[alpha 2 beta 2 6(A3)Glu----Lys] in cord blood using a monoclonal antibody.

doi:10.1002/ajh.2830330308

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Article

Simple and rapid enzyme-linked immunosorbent assay for the detection of hemoglobin C[alpha 2 beta 2 6(A3)Glu----Lys] in cord blood using a monoclonal antibody.

American journal of hematology - 1 Mar 1990

Shyamala M, Kiefer C R, Moscoso H, Garver F A

Abstract excerpt

We have generated a murine hybridoma that secretes a monoclonal antibody (mAb) that is highly specific for hemoglobin C (HbC) [alpha 2 beta 2 6(A3)Glu----Lys] and shows no cross reactivity with HbA, HbA2, HbF, HbS, HbE, or Hb O-Arab. Using this antibody, we developed a simple and rapid enzyme lin...

Topics

Animals
Antibodies, Monoclonal
Enzyme-Linked Immunosorbent Assay
Fetal Blood
Hemoglobin C
Hybridomas
Mice
Mice, Inbred BALB C
Phenotype
Sensitivity and Specificity

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