Article
Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2013
Rader Julieann, Russell Mike R, Hart Lori S, Nakazawa Michael S, Belcastro Lili T, Martinez Daniel, Li Yimei, Carpenter Erica L, Attiyeh Edward F, Diskin Sharon J, Kim Sunkyu, Parasuraman Sudha, Caponigro Giordano, Schnepp Robert W, Wood Andrew C, Pawel Bruce, Cole Kristina A, Maris John M
Abstract excerpt
PURPOSE: Neuroblastoma is a pediatric cancer that continues to exact significant morbidity and mortality. Recently, a number of cell-cycle proteins, particularly those within the Cyclin D/CDK4/CDK6/RB network, have been shown to exert oncogenic roles in neuroblastoma, suggesting that their therapeutic exploitation might improve patient outcomes. EXPERIMENTAL PROCEDURES: We evaluated the effect of dual CDK4/CDK6...
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