Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An experimental test on the probability of extinction of new genetic variants.

Nature communications - 1 Jan 2013

Chelo Ivo M, Nédli Judit, Gordo Isabel, Teotónio Henrique

Abstract excerpt

In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost with high probability. Here we demonstrate that extinction rates decrease with increasing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Caenorhabditis elegans
Share to Extinction, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Drift

Share to Models, Biological

Share to Polymorphism, Genetic

Share to Probability

Share to Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 24030070
DOI: 10.1038/ncomms3417
PMCID: PMC3778522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An experimental test on the probability of extinction of new genetic variants.PMID 24030070Read ↗

Loss and fixation of strongly favoured new variants: Understanding and extending Haldane's result via the Wright-Fisher model.Semantic proximity Read ↗

Mutant invasions and adaptive dynamics in variable environments.Semantic proximity Read ↗

Model and test in a fungus of the probability that beneficial mutations survive drift.Semantic proximity Read ↗

The fixation probability of beneficial mutations.Semantic proximity Read ↗

The fixation of locally beneficial alleles in a metapopulation.Semantic proximity Read ↗

Probability of fixation under weak selection: a branching process unifying approach.Semantic proximity Read ↗

Experimental determination of invasive fitness in Caenorhabditis elegans.Semantic proximity Read ↗

Population extinction and the genetics of adaptation.Semantic proximity Read ↗

The population genetics of evolutionary rescue.Semantic proximity Read ↗

The distribution of beneficial mutant effects under strong selection.Semantic proximity Read ↗

The inevitability of unconditionally deleterious substitutions during adaptation.Semantic proximity Read ↗

The distribution of fitness effects among beneficial mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.