Article
Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility.
PloS one - 1 Jan 2013
Chang Chia-Jung, Kuo Ho-Chang, Chang Jeng-Sheng, Lee Jong-Keuk, Tsai Fuu-Jen, Khor Chiea Chuen, Chang Li-Ching, Chen Shih-Ping, Ko Tai-Ming, Liu Yi-Min, Chen Ying-Ju, Hong Young Mi, Jang Gi Young, Hibberd Martin L, Kuijpers Taco, Burgner David, Levin Michael, Burns Jane C, Davila Sonia, Chen Yuan-Tsong, Chen Chien-Hsiun, Wu Jer-Yuarn, Lee Yi-Ching
Abstract excerpt
The BLK and CD40 loci have been associated with Kawasaki disease (KD) in two genome-wide association studies (GWAS) conducted in a Taiwanese population of Han Chinese ancestry (Taiwanese) and in Japanese cohorts. Here we build on these findings with replication studies of the BLK and CD40 loci in populations of Korean and European descent. The BLK region was significantly associated with KD susceptibility in both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.