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Salmonella Gallinarum field isolates from laying hens are related to the vaccine strain SG9R.

Vaccine - 9 Oct 2013

Van Immerseel F, Studholme D J, Eeckhaut V, Heyndrickx M, Dewulf J, Dewaele I, Van Hoorebeke S, Haesebrouck F, Van Meirhaeghe H, Ducatelle R, Paszkiewicz K, Titball R W

Abstract excerpt

Salmonella enterica subspecies enterica serotype Gallinarum can cause severe systemic disease in chickens and a live Salmonella Gallinarum 9R vaccine (SG9R) has been used widely to control disease. Using whole-genome sequencing we found point mutations in the pyruvate dehydrogenase (aceE) and/or lipopolysaccharide 1,2-glucosyltransferase (rfaJ) genes that likely explain the attenuation of the SG9R vaccine strain....

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PMID: 23994381
DOI: 10.1016/j.vaccine.2013.08.033

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