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Article

Developmental-like bone regeneration by human embryonic stem cell-derived mesenchymal cells.

Tissue engineering. Part A - 1 Jan 2014

Kuhn Liisa T, Liu Yongxing, Boyd Nolan L, Dennis James E, Jiang Xi, Xin Xiaonan, Charles Lyndon F, Wang Liping, Aguila H Leonardo, Rowe David W, Lichtler Alexander C, Goldberg A Jon

Abstract excerpt

The in vivo osteogenesis potential of mesenchymal-like cells derived from human embryonic stem cells (hESC-MCs) was evaluated in vivo by implantation on collagen/hydroxyapatite scaffolds into calvarial defects in immunodeficient mice. This study is novel because no osteogenic or chondrogenic differentiation protocols were applied to the cells prior to implantation. After 6 weeks, X-ray, microCT, and histological...

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Identifiers

PMID: 23952622
DOI: 10.1089/ten.TEA.2013.0321
PMCID: PMC4350005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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