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Article

Campylobacter jejuni pdxA affects flagellum-mediated motility to alter host colonization.

PloS one - 1 Jan 2013

Asakura Hiroshi, Hashii Noritaka, Uema Masashi, Kawasaki Nana, Sugita-Konishi Yoshiko, Igimi Shizunobu, Yamamoto Shigeki

Abstract excerpt

Vitamin B6 (pyridoxal-5'-phosphate, PLP) is linked to a variety of biological functions in prokaryotes. Here, we report that the pdxA (putative 4-hydroxy-L-threonine phosphate dehydrogenase) gene plays a pivotal role in the PLP-dependent regulation of flagellar motility, thereby altering host colonization in a leading foodborne pathogen, Campylobacter jejuni. A C. jejuni pdxA mutant failed to produce PLP and...

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Source

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Identifiers

PMID: 23936426
DOI: 10.1371/journal.pone.0070418
PMCID: PMC3735588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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