Article
Origin and functional diversification of an amphibian defense peptide arsenal.
PLoS genetics - 1 Jan 2013
Roelants Kim, Fry Bryan G, Ye Lumeng, Stijlemans Benoit, Brys Lea, Kok Philippe, Clynen Elke, Schoofs Liliane, Cornelis Pierre, Bossuyt Franky
Abstract excerpt
The skin secretion of many amphibians contains an arsenal of bioactive molecules, including hormone-like peptides (HLPs) acting as defense toxins against predators, and antimicrobial peptides (AMPs) providing protection against infectious microorganisms. Several amphibian taxa seem to have independently acquired the genes to produce skin-secreted peptide arsenals, but it remains unknown how these originated from...
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