Article
Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila.
Genetics - 1 Oct 2013
Long Hong-An, Paixão Tiago, Azevedo Ricardo B R, Zufall Rebecca A
Abstract excerpt
Knowledge of the rate and fitness effects of mutations is essential for understanding the process of evolution. Mutations are inherently difficult to study because they are rare and are frequently eliminated by natural selection. In the ciliate Tetrahymena thermophila, mutations can accumulate in the germline genome without being exposed to selection. We have conducted a mutation accumulation (MA) experiment in...
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