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Article

Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.

The Journal of biological chemistry - 13 Sept 2013

Kwon Heung Sun, Johnson Thomas V, Joe Myung Kuk, Abu-Asab Mones, Zhang Jun, Chan Chi Chao, Tomarev Stanislav I

Abstract excerpt

The glaucoma-associated gene, myocilin, is expressed in ocular and non-ocular tissues including the peripheral nervous system, but its functions in these tissues remain poorly understood. We demonstrate that in sciatic nerve, myocilin is expressed in Schwann cells with high concentrations at the nodes of Ranvier. There, myocilin interacts with gliomedin, neurofascin, and NrCAM, which are essential for node...

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Source

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Identifiers

PMID: 23897819
DOI: 10.1074/jbc.M112.446138
PMCID: PMC3772183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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