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Article

Three distinct two-component systems are involved in resistance to the class I bacteriocins, Nukacin ISK-1 and nisin A, in Staphylococcus aureus.

PloS one - 1 Jan 2013

Kawada-Matsuo Miki, Yoshida Yuuma, Zendo Takeshi, Nagao Junichi, Oogai Yuichi, Nakamura Yasunori, Sonomoto Kenji, Nakamura Norifumi, Komatsuzawa Hitoshi

Abstract excerpt

Staphylococcus aureus uses two-component systems (TCSs) to adapt to stressful environmental conditions. To colonize a host, S. aureus must resist bacteriocins produced by commensal bacteria. In a comprehensive analysis using individual TCS inactivation mutants, the inactivation of two TCSs, graRS and braRS, significantly increased the susceptibility to the class I bacteriocins, nukacin ISK-1 and nisin A, and...

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Identifiers

PMID: 23894484
DOI: 10.1371/journal.pone.0069455
PMCID: PMC3718698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Three distinct two-component systems are involved in resistance to the class I bacteriocins, Nukacin ISK-1 and nisin A, in Staphylococcus aureus.PMID 23894484Read ↗

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