Article
Three distinct two-component systems are involved in resistance to the class I bacteriocins, Nukacin ISK-1 and nisin A, in Staphylococcus aureus.
PloS one - 1 Jan 2013
Kawada-Matsuo Miki, Yoshida Yuuma, Zendo Takeshi, Nagao Junichi, Oogai Yuichi, Nakamura Yasunori, Sonomoto Kenji, Nakamura Norifumi, Komatsuzawa Hitoshi
Abstract excerpt
Staphylococcus aureus uses two-component systems (TCSs) to adapt to stressful environmental conditions. To colonize a host, S. aureus must resist bacteriocins produced by commensal bacteria. In a comprehensive analysis using individual TCS inactivation mutants, the inactivation of two TCSs, graRS and braRS, significantly increased the susceptibility to the class I bacteriocins, nukacin ISK-1 and nisin A, and...
Topics
- ATP-Binding Cassette Transporters
- Bacteriocins
- Coculture Techniques
- Drug Resistance, Bacterial
- Gene Expression Regulation, Bacterial
- Lactococcus lactis
- Mutation
- Nisin
- Staphylococcus aureus