Article
Multi-SNP analysis of GWAS data identifies pathways associated with nonalcoholic fatty liver disease.
PloS one - 1 Jan 2013
Chen Qing-Rong, Braun Rosemary, Hu Ying, Yan Chunhua, Brunt Elizabeth M, Meerzaman Daoud, Sanyal Arun J, Buetow Kenneth
Abstract excerpt
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease; the histological spectrum of which ranges from steatosis to steatohepatitis. Nonalcoholic steatohepatitis (NASH) often leads to cirrhosis and development of hepatocellular carcinoma. To better understand pathogenesis of NAFLD, we performed the pathway of distinction analysis (PoDA) on a genome-wide association study dataset of 250 non-Hispanic...
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