Article
The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and coronaviruses are evolutionarily related.
Nucleic acids research - 11 Aug 1990
Snijder E J, den Boon J A, Bredenbeek P J, Horzinek M C, Rijnbrand R, Spaan W J
Abstract excerpt
Sequence analysis of the 3' part (8 kb) of the polymerase gene of the torovirus prototype Berne virus (BEV) revealed that this area contains at least two open reading frames (provisionally designated ORF1a and ORF1b) which overlap by 12 nucleotides. The complete sequence of ORF1b (6873 nucleotides) was determined. Like the coronaviruses, BEV was shown to express its ORF1b by ribosomal frameshifting during...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Cell Line
- Cloning, Molecular
- Coronaviridae
- DNA-Directed RNA Polymerases
- Genes, Viral
- HeLa Cells
- Molecular Sequence Data