Article
Blurring the boundaries: developmental and activity-dependent determinants of neural circuits.
Trends in neurosciences - 1 Oct 2013
Wolfram Verena, Baines Richard A
Abstract excerpt
The human brain comprises approximately 100 billion neurons that express a diverse, and often subtype-specific, set of neurotransmitters and voltage-gated ion channels. Given this enormous complexity, a fundamental question is how is this achieved? The acquisition of neurotransmitter phenotype was viewed as being set by developmental programs 'hard wired' into the genome. By contrast, the expression of...
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