Article
Large-scale screens of miRNA-mRNA interactions unveiled that the 3'UTR of a gene is targeted by multiple miRNAs.
PloS one - 1 Jan 2013
Zhou Peng, Xu Weiyi, Peng Xueling, Luo Zhenhua, Xing Qinghe, Chen Xulin, Hou Chengqian, Liang Weihong, Zhou Jianwen, Wu Xiaoyan, Songyang Zhou, Jiang Songshan
Abstract excerpt
Animal microRNA (miRNA) target prediction is still a challenge, although many prediction programs have been exploited. MiRNAs exert their function through partially binding the messenger RNAs (mRNAs; likely at 3' untranslated regions [3'UTRs]), which makes it possible to detect the miRNA-mRNA interactions in vitro by co-transfection of miRNA and a luciferase reporter gene containing the target mRNA fragment into...
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