Article
Synapse location during growth depends on glia location.
Cell - 18 Jul 2013
Shao Zhiyong, Watanabe Shigeki, Christensen Ryan, Jorgensen Erik M, Colón-Ramos Daniel A
Abstract excerpt
Synaptic contacts are largely established during embryogenesis and are then maintained during growth. To identify molecules involved in this process, we conducted a forward genetic screen in C. elegans and identified cima-1. In cima-1 mutants, synaptic contacts are correctly established during embryogenesis, but ectopic synapses emerge during postdevelopmental growth. cima-1 encodes a solute carrier in the SLC17...
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