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Article

Purine metabolism during neuronal differentiation: the relevance of purine synthesis and recycling.

Journal of neurochemistry - 1 Dec 2013

Göttle Martin, Burhenne Heike, Sutcliffe Diane, Jinnah H A

Abstract excerpt

Purines are a class of small organic molecules that are essential for all cells. They play critical roles in neuronal differentiation and function. Their importance is highlighted by several inherited disorders of purine metabolism, such as Lesch-Nyhan disease, which is caused by a deficiency of the purine salvage enzyme, hypoxanthine-guanine phosphoribosyltransferase (HGprt). Despite the known importance of...

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Identifiers

PMID: 23859490
DOI: 10.1111/jnc.12366
PMCID: PMC3859826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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