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Article

Angiogenin Mediates Androgen-Stimulated Prostate Cancer Growth and Enables Castration Resistance

13 Jul 2013

Abstract excerpt

UNLABELLED: The androgen receptor (AR) is a critical effector of prostate cancer development and progression. Androgen-dependent prostate cancer is reliant on the function of AR for growth and progression. Most castration-resistant prostate cancer (CRPC) remains dependent on AR signaling for survival and growth. Ribosomal RNA (rRNA) is essential for both androgen-dependent and castration-resistant growth of...

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PMID: 23851444
DOI: 10.1158/1541-7786.mcr-13-0072

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