Structural and Functional Integrity of Spermatozoa Is Compromised as a Consequence of Acute Uropathogenic E. coli-Associated Epididymitis1

Abstract excerpt

Uropathogenic Escherichia coli (UPEC)-associated epididymitis is commonly diagnosed in outpatient settings. Although the infection can be successfully cleared using antimicrobial medications, 40% of patients unexplainably show persistent impaired semen parameters even after treatment. Our aim was to investigate whether pathogenic UPEC and its associated virulence factor hemolysin (hlyA) perturb the structural and...

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