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Article

Deconstructing Mitochondrial Dysfunction in Alzheimer Disease

1 Jan 2013

Abstract excerpt

There is mounting evidence showing that mitochondrial damage plays an important role in Alzheimer disease. Increased oxygen species generation and deficient mitochondrial dynamic balance have been suggested to be the reason as well as the consequence of Alzheimer-related pathology. Mitochondrial damage has been related to amyloid-beta or tau pathology or to the presence of specific presenilin-1 mutations. The...

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PMID: 23840916
DOI: 10.1155/2013/162152

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