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Article

IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium.

Placenta - 1 Sept 2013

Nguyen T, Robinson N, Allison S E, Coombes B K, Sad S, Krishnan L

Abstract excerpt

INTRODUCTION: Salmonella enterica Typhimurium (ST) is a phagosomal pathogen that can infect placental trophoblast cells leading to abortion and severe maternal illness. It is unclear how the trophoblast cells promote profound bacterial proliferation. METHODS: The mechanism of internalization, intracellular growth and phagosomal biogenesis in ST-infected human epithelial (HeLa), macrophage (THP-1) and...

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Source

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Identifiers

PMID: 23834952
DOI: 10.1016/j.placenta.2013.06.003
PMCID: PMC3797447

Genes

LAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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