Article
Genetic counselling in ALS: facts, uncertainties and clinical suggestions.
Journal of neurology, neurosurgery, and psychiatry - 1 May 2014
Chiò Adriano, Battistini Stefania, Calvo Andrea, Caponnetto Claudia, Conforti Francesca L, Corbo Massimo, Giannini Fabio, Mandrioli Jessica, Mora Gabriele, Sabatelli Mario, Ajmone Clara, Mastro Enza, Pain Debora, Mandich Paola, Penco Silvana, Restagno Gabriella, Zollino Marcella, Surbone Antonella
Abstract excerpt
The clinical approach to patients with amyotrophic lateral sclerosis (ALS) has been largely modified by the identification of novel genes, the detection of gene mutations in apparently sporadic patients, and the discovery of the strict genetic and clinical relation between ALS and frontotemporal dementia (FTD). As a consequence, clinicians are increasingly facing the dilemma on how to handle genetic counselling...
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