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Article

Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons.

Human molecular genetics - 1 Nov 2013

Jiao Jiao, Yang Yuanyuan, Shi Yiwu, Chen Jiayu, Gao Rui, Fan Yong, Yao Hui, Liao Weiping, Sun Xiao-Fang, Gao Shaorong

Abstract excerpt

Severe myoclonic epilepsy of infancy (SMEI, also known as Dravet syndrome) and genetic epilepsy with febrile seizures plus (mild febrile seizures) can both arise due to mutations of SCN1A, the gene encoding alpha 1 pore-forming subunit of the Nav1.1 voltage-gated sodium channel. Owing to the inaccessibility of patient brain neurons, the precise mechanism of mild febrile seizures and SMEI remains elusive, and...

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Identifiers

PMID: 23773995
DOI: 10.1093/hmg/ddt275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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