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Article

Primary immunodeficiencies predisposed to Epstein‐Barr virus‐driven haematological diseases

11 Jun 2013

Abstract excerpt

Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, maintains lifelong subclinical persistent infections in humans. In the circulation, EBV primarily infects the B cells, and protective immunity is mediated by EBV-specific cytotoxic T cells (CTLs) and natural killer (NK) cells. However, EBV has been linked to several devastating diseases, such as haemophagocytic lymphohistiocytosis (HLH) and...

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PMID: 23758097
DOI: 10.1111/bjh.12422

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