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Article

Primary immunodeficiency diseases: an update.

The Journal of allergy and clinical immunology - 1 Sept 2004

Notarangelo Luigi, Casanova Jean-Laurent, Fischer Alain, Puck Jennifer, Rosen Fred, Seger Reinhard, Geha Raif

Abstract excerpt

Although relatively rare, primary immune deficiency diseases (PIDs) provide an excellent window into the functioning of the immune system. In the late 1960s, observations on these diseases, with their associated infections and genetics, bisected the immune system into humoral immunity and cell-mediated immunity. These diseases also represent a challenge in their diagnosis and treatment. Beginning in 1970, a...

Topics

Animals
Antibody Formation
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
Immunity, Cellular
Immunity, Innate
Immunologic Deficiency Syndromes
International Cooperation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Mutation

Societies, Scientific

Source

Identifiers

PMID: 15356576
DOI: 10.1016/j.jaci.2004.06.044

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