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Article

Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice

4 Jun 2013

Abstract excerpt

microRNAs (miRNAs) are dysregulated in a variety of disease states, suggesting that this newly discovered class of gene expression repressors may be viable therapeutic targets. A microarray of miRNA changes in ALS-model superoxide dismutase 1 (SOD1)(G93A) rodents identified 12 miRNAs as significantly changed. Six miRNAs tested in human ALS tissues were confirmed increased. Specifically, miR-155 was increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23740943
DOI: 10.1093/hmg/ddt261

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