Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial.

doi:10.1016/S1470-2045(13)70163-3

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Article

Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial.

The Lancet. Oncology - 1 Jul 2013

Seymour Matthew T, Brown Sarah R, Middleton Gary, Maughan Timothy, Richman Susan, Gwyther Stephen, Lowe Catherine, Seligmann Jennifer F, Wadsley Jonathan, Maisey Nick, Chau Ian, Hill Mark, Dawson Lesley, Falk Stephen, O'Callaghan Ann, Benstead Kim, Chambers Philip, Oliver Alfred, Marshall Helen, Napp Vicky, Quirke Phil

Abstract excerpt

BACKGROUND: Therapeutic antibodies targeting EGFR have activity in advanced colorectal cancer, but results from clinical trials are inconsistent and the population in which most benefit is derived is uncertain. Our aim was to assess the addition of panitumumab to irinotecan in pretreated advanced colorectal cancer. METHODS: In this open-label, randomised trial, we enrolled patients who had advanced colorectal...

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Identifiers

PMID: 23725851
DOI: 10.1016/S1470-2045(13)70163-3
PMCID: PMC3699713

Genes

EGFR
KRAS
BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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