Article
Gamma interferon receptor defect presenting as recurrent tuberculosis.
Indian journal of pediatrics - 1 Jul 2014
Sundaram Balasubramanian, Amperayani Sumanth, Dhanalakshmi K, Padmanaban Swathi
Abstract excerpt
Failure of response to therapy in childhood tuberculosis may be due to resistance, paradoxical response or immunodeficiency. Interferon-γ (IFNγ) plays a major role during host defense against Mycobacterium tuberculosis (Mtb). An 8-y-old boy presented with fever, hepatosplenomegaly and parotid abscess. He had been earlier treated for BCG adenitis in infancy and at 5 y for TB osteomyelitis of iliac bone and...
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