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Article

MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion.

Molecular and cellular biochemistry - 1 Aug 2013

Yu Ge, Li Hui, Wang Xin, Wu Tao, Zhu Jing, Huang Shanjun, Wan Yuanlian, Tang Jianqiang

Abstract excerpt

The over-expression of tissue factor (TF) and its roles in colon cancer progression have attracted much attention. However, the mechanisms regulating TF expression have not yet been shown in detail. In this study, we over-expressed miR-19a, miR20a and miR-106b in colon cancer cells, and evaluated their impact on TF expression and cellular function. We provide evidence demonstrating that miR-19a inhibited TF...

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PMID: 23666757
DOI: 10.1007/s11010-013-1679-6

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