Article
Overo lethal white foal syndrome: equine model of aganglionic megacolon (Hirschsprung disease).
American journal of medical genetics - 1 Jul 1990
McCabe L, Griffin L D, Kinzer A, Chandler M, Beckwith J B, McCabe E R
Abstract excerpt
The lethal white foal syndrome (LWFS) is a congenital abnormality of overo spotted horses which is a model for human aganglionic megacolon or Hirschsprung disease. Foals with LWFS have an all white, or nearly all white, coat. They also present clinically with an intestinal obstruction that proves fatal within the first few days of life. The LWFS involves both melanocytes and intestinal ganglion cells, and appears...
Topics
- Animals
- Disease Models, Animal
- Genes, Dominant
- Hirschsprung Disease
- Horse Diseases
- Horses
- Intestinal Obstruction
- Mutation
- Syndrome