Article
Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial.
JAMA - 1 May 2013
Dobson Simon R M, McNeil Shelly, Dionne Marc, Dawar Meena, Ogilvie Gina, Krajden Mel, Sauvageau Chantal, Scheifele David W, Kollmann Tobias R, Halperin Scott A, Langley Joanne M, Bettinger Julie A, Singer Joel, Money Deborah, Miller Dianne, Naus Monika, Marra Fawziah, Young Eric
Abstract excerpt
IMPORTANCE: Global use of human papillomavirus (HPV) vaccines to prevent cervical cancer is impeded by cost. A 2-dose schedule for girls may be possible. OBJECTIVE: To determine whether mean antibody levels to HPV-16 and HPV-18 among girls receiving 2 doses was noninferior to women receiving 3 doses. DESIGN, SETTING, AND PATIENTS: Randomized, phase 3, postlicensure, multicenter, age-stratified, noninferiority...
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