Article
The epigenetic language of circadian clocks.
Handbook of experimental pharmacology - 1 Jan 2013
Sahar Saurabh, Sassone-Corsi Paolo
Abstract excerpt
Epigenetic control, which includes DNA methylation and histone modifications, leads to chromatin remodeling and regulated gene expression. Remodeling of chromatin constitutes a critical interface of transducing signals, such as light or nutrient availability, and how these are interpreted by the cell to generate permissive or silenced states for transcription. CLOCK-BMAL1-mediated activation of clock-controlled...
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