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A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo

17 Apr 2013

Abstract excerpt

Leukemia stem cells (LSCs) that survive conventional chemotherapy are thought to contribute to disease relapse, leading to poor long-term outcomes for patients with acute myeloid leukemia (AML). We previously identified a Src-family kinase (SFK) member, hematopoietic cell kinase (HCK), as a molecular target that is highly differentially expressed in human primary LSCs compared with human normal hematopoietic stem...

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PMID: 23596204
DOI: 10.1126/scitranslmed.3004387

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