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Article

Complexity of resistance mechanisms to imipenem in intensive care unit strains of Pseudomonas aeruginosa.

The Journal of antimicrobial chemotherapy - 1 Aug 2013

Fournier Damien, Richardot Charlotte, Müller Emeline, Robert-Nicoud Marjorie, Llanes Catherine, Plésiat Patrick, Jeannot Katy

Abstract excerpt

BACKGROUND: Pseudomonas aeruginosa can become resistant to carbapenems by both intrinsic (mutation-driven) and transferable (β-lactamase-based) mechanisms. Knowledge of the prevalence of these various mechanisms is important in intensive care units (ICUs) in order to define optimal prevention and therapeutic strategies. METHODS: A total of 109 imipenem-non-susceptible (MIC >4 mg/L) strains of P. aeruginosa were...

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PMID: 23587654
DOI: 10.1093/jac/dkt098

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