Article
Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment.
Human molecular genetics - 1 Aug 2013
Kirin Mirna, Chandra Aman, Charteris David G, Hayward Caroline, Campbell Susan, Celap Ivana, Bencic Goran, Vatavuk Zoran, Kirac Iva, Richards Allan J, Tenesa Albert, Snead Martin P, Fleck Brian W, Singh Jaswinder, Harsum Steven, Maclaren Robert E, den Hollander Anneke I, Dunlop Malcolm G, Hoyng Carel B, Wright Alan F, Campbell Harry, Vitart Veronique, Mitry Danny
Abstract excerpt
Rhegmatogenous retinal detachment (RRD) is an important cause of vision loss and can potentially lead to blindness. The underlying pathogenesis is complex and incompletely understood. We applied a two-stage genetic association discovery phase followed by a replication phase in a combined total of 2833 RRD cases and 7871 controls. The discovery phase involved a genome-wide association scan of 867 affected...
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