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Article

Detection of ancestry informative HLA alleles confirms the admixed origins of Japanese population.

PloS one - 1 Jan 2013

Nakaoka Hirofumi, Mitsunaga Shigeki, Hosomichi Kazuyoshi, Shyh-Yuh Liou, Sawamoto Taiji, Fujiwara Tsutomu, Tsutsui Naohisa, Suematsu Koji, Shinagawa Akira, Inoko Hidetoshi, Inoue Ituro

Abstract excerpt

The polymorphisms in the human leukocyte antigen (HLA) region are powerful tool for studying human evolutionary processes. We investigated genetic structure of Japanese by using five-locus HLA genotypes (HLA-A, -B, -C, -DRB1, and -DPB1) of 2,005 individuals from 10 regions of Japan. We found a significant level of population substructure in Japanese; particularly the differentiation between Okinawa Island and...

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Identifiers

PMID: 23577161
DOI: 10.1371/journal.pone.0060793
PMCID: PMC3618337

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Source receipt: pubmed, retrieved 7 Sept 2026.

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